ContiStain: Cross-Domain Relation-Preserving Distillation for Continual Multi-Domain Virtual IHC Staining
A unified multiplex virtual staining model enables scalable and non-destructive multiplex analysis from H&E slides while promoting parameter efficiency, shared pathological knowledge, and consistent cross-biomarker representations. However, in clinical practice, data for new biomarkers are typically acquired sequentially over time. Fine-tuning on such temporally arriving data leads to severe performance degradation on previously learned biomarkers, as sequential optimization disrupts the structured relationships among biomarker representations in the latent space. To address this issue, we propose ContiStain, an IHC multi-domain relational distillation framework for continual virtual stai...
| Authors | Fuqiang Chen, Yifeng Wang, Hongpeng Wang et al. |
|---|---|
| Primary category | cs.CV |
| Published | 4 July 2026 |
| Last updated at source | 4 July 2026 |
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