Folding, Reasoning, and Scaling with Open-source Drug Discovery Engine
Accurately modeling biomolecular interactions is a central bottleneck in biology and therapeutic discovery. Here, we introduce Open Drug Discovery Engine (OpenDDE), an open-source, all-atom biomolecular foundation model that uses co-folding as the entry point to a scalable AI-driven drug discovery engine. Rather than treating structure prediction as an isolated endpoint, OpenDDE is designed as a shared structural reasoning layer for modeling sequence-structure-function relationships across biomolecular complexes, enabling complex structure prediction today while providing a foundation for de novo design, affinity estimation, structure-conditioned optimization, and more. OpenDDE integrates...
| Authors | Aureka AI OpenDDE project |
|---|---|
| Primary category | cs.AI |
| Published | 4 July 2026 |
| Last updated at source | 4 July 2026 |
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