Multipath Adaptive Gated Bottleneck Latent ODE with Raman Data Fusion for Cell Culture Process Forecasting
Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-specification trend is often confirmed too late to intervene. Early-stage, multi-day forecasts could enable timely adjustment of feeding, sampling, and control, but bioprocess forecasting is challenging because measurements are sparse and irregularly sampled, operating conditions are heterogeneous across cell lines and media, and runs with near-identical early behaviour can diverge into different futures. We propose an adaptive framework combining a Gated Bottleneck Latent Ordinary Differential Equation (GB-Latent...
| Authors | Johnny Peng, Thanh Tung Khuat, Ellen Otte et al. |
|---|---|
| Primary category | cs.LG |
| Published | 25 June 2026 |
| Last updated at source | 3 July 2026 |
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