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Paper · arXiv

SP-Mind: An Autonomous Reasoning Agent for Spatial Proteomics Analysis

Spatial proteomics enables single-cell-resolution characterization of protein expression within tissue architecture, playing a critical role in understanding tumor microenvironments and guiding precision medicine. However, current analysis workflows remain fragmented, requiring expert manual orchestration of heterogeneous tools and limiting research scalability and reproducibility. We present SP-Mind, the first autonomous AI agent designed to unify the spatial proteomics analysis pipeline, from raw multiplexed tissue imaging to downstream phenotype discovery. Equipped with expert-curated biological analysis skills and specialized computational tools, SP-Mind converts natural-language quer...

AuthorsYucheng Yuan, Yuanfeng Ji, Zhongxiao Li et al.
Primary categorycs.AI
Published23 June 2026
Last updated at source6 August 2026
cs.AI
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