Delta-Diffusion: Modeling Longitudinal Brain Amyloid-PET Trajectories via Conditional Poisson Diffusion Bridge
While longitudinal brain PET imaging is the gold standard for quantifying the spatiotemporal accumulation of Beta-amyloid, its widespread clinical utility is constrained by high operational costs and cumulative radiation risks. Recent deep generative models show promise in longitudinal image synthesis; however, they often fail to capture subtle pathological progression due to identity drift and a persistent bias toward trivially replicating baseline signal intensities rather than modeling temporal transition. To this end, we propose Delta-Diffusion, a novel progression-aware framework that redefines longitudinal PET synthesis as a conditional Poisson Diffusion Bridge (PDB) process. Unlike...
| Authors | Yongheng Sun, Minhui Yu, Mengqi Wu et al. |
|---|---|
| Primary category | eess.IV |
| Published | 20 June 2026 |
| Last updated at source | 4 August 2026 |
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