DART: A design-aware microfluidic chip paradigm for real-time live-cell image analysis
High-throughput microfluidic live-cell imaging generates rich single-cell data. Yet semi-automated procedures for locating regions of interest (RoIs), each containing one cell population, and removing surrounding microfluidic structures from recorded images, scale with the number of RoIs. This prevents real-time image analysis and delays time-to-insight by hours to days. We introduce the Design-Aware and Real-Time capable (DART) paradigm for microfluidic cultivation chips, which aligns the CAD blueprint with the physical chip and thereby enables throughput-independent localization of all RoIs and fully automated image processing across diverse RoI geometries and chip layouts. DART establi...
| Authors | Johannes Seiffarth, Matthias Pesch, Lukas Scholtes et al. |
|---|---|
| Primary category | q-bio.QM |
| Published | 16 June 2026 |
| Last updated at source | 16 June 2026 |
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