Patients With Personality: Realistic Patient Simulation through Controlled Diversity and Selective Disclosure
Simulating realistic patient interactions is a key requirement to testing clinical applications of LLMs at scale without time-consuming and expensive user studies. However, existing approaches often lack realism and controllability, often oversharing information unprompted, and failing to capture the wide variability of patient behavior. Here, we introduce PatientsWithPersonality (PWP), a patient simulation framework that generates realistic yet diverse virtual patient responses through explicit personality parametrization over a latent patient state. Grounded in HEXACO, a six-dimensional personality space used to quantify and parameterize human behavioral traits, our approach enables fin...
| Authors | Moritz Schlager, Friederike Jungmann, Samuel Schmidgall et al. |
|---|---|
| Primary category | cs.HC |
| Published | 13 May 2026 |
| Last updated at source | 11 August 2026 |
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