Lesion-DDPM: Lesion-Enhanced 3D Diffusion for MS MRI Synthesis
3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns. This scarcity and variability hinder the development of robust neuroimaging machine learning models and are particularly challenging for generative models that aim to synthesize images while preserving small, sparse lesions. We propose Lesion-DDPM, a 3D conditional diffusion framework for lesion-aware FLAIR synthesis that incorporates multi-level anatomical mask injection together with a lesion-weighted reconstruction loss to emphasize lesion vox...
| Authors | Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik et al. |
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| Primary category | cs.CV |
| Published | 13 June 2026 |
| Last updated at source | 8 October 2026 |
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