FreeBridge: Variational Schrödinger Bridges for Cellular Transition Dynamics
High-content imaging assays quantify cellular responses to chemical and genetic perturbations, yet continuous trajectories of individual cells are unobservable because cells are chemically fixed at acquisition. Perturbation modeling therefore reduces to inferring stochastic transport between control and treated populations observed only as separate marginals. While recent generative models achieve strong end-point alignment, boundary consistency does not determine intermediate evolution: multiple stochastic processes may connect identical marginals while traversing regions unsupported by observed single-cell morphologies. We introduce \textbf{FreeBridge}, a Schrödinger Bridge formulation ...
| Authors | Xurui Wang, Qin Ren, Jun Ma et al. |
|---|---|
| Primary category | cs.LG |
| Published | 9 June 2026 |
| Last updated at source | 9 June 2026 |
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