Routine laboratory trajectories encode the onset of organ-level complications in cancer
Routine laboratory panels drawn during cancer treatment constitute longitudinal physiological recordings of organ function, yet their temporal structure is discarded by single-timepoint prognostic tools. A transformer trained on 2,777,595 laboratory measurements from 3,905 patients with multiple myeloma or ovarian cancer predicted the two-year onset of 162 treatment-associated complications, including therapy-related myelodysplastic syndromes, spanning eight clinical categories, achieving 1.5- to 6.1-fold enrichment above prevalence at the group level. It matched or outperformed non-sequential baselines across grouped endpoints (AUROC gains up to +0.11), demonstrating that longitudinal la...
| Authors | Jannik Lübberstedt, Krischan Braitsch, Jacqueline Lammert et al. |
|---|---|
| Primary category | cs.LG |
| Published | 7 June 2026 |
| Last updated at source | 7 June 2026 |
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