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Paper · arXiv

Integrating Mechanistic and Data-Driven Models for Neurological Disorders through Differentiable Programming

Advances in computational modeling, neuroimaging, and artificial intelligence are revolutionizing the modeling of neurological disorders for improved diagnostics, prognosis, and treatment planning. Mechanistic models provide valuable scientific insight into the disorders, but in practice they are often simplified with assumptions or computationally expensive and slow to solve. However, while purely data driven approaches provide speed and scalability, they require large, high quality data to train and generally suffer from interpretability and generalization issues. This perspective paper presents a structured overview of hybrid modeling strategies, which combine deep learning models with...

AuthorsShah Pallav Dhanendrakumar, Saikat Pal, Sitikantha Roy
Primary categorycs.AI
Published4 June 2026
Last updated at source4 June 2026
cs.AIcs.LGmath.DSphysics.med-ph
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