Mos-Gen: A Generative Molecular Framework for Mosquito Insecticide Design
Mosquito-borne infectious diseases cause more than 700000 deaths worldwide each year. The long-term use of conventional chemical insecticides has induced serious resistance problems, creating an urgent need to develop novel, highly effective, and ecologically sustainable alternatives. While existing artificial intelligence approaches in this domain have focused primarily on activity prediction and classification, they leave a critical gap in the de~novo generation of novel molecular scaffolds. In this study, we propose Mos-Gen, a motif-aware generative collaborative framework that couples the pretrained molecular representation model Uni-Mol with a variational autoencoder (VAE), specifica...
| Authors | Lina Wang, Yaning Cui, Zhifeng Gao et al. |
|---|---|
| Primary category | cs.LG |
| Published | 1 June 2026 |
| Last updated at source | 18 August 2026 |
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