CryoProt: A Protein Pretraining Framework with Cross-Box Interactions on Cryo-EM Density Maps
Despite the growing availability of cryo-electron microscopy (cryo-EM) density maps, effectively leveraging them for protein representation remains challenging. First, current methods lack a general-purpose protein pretraining framework tailored for cryo-EM density maps, designed for protein-related property prediction. Second, existing approaches typically partition density maps into local box regions and model them independently, overlooking interactions across boxes which are essential for capturing global structural context in cryo-EM density map. To address these challenges, we propose CryoProt, a protein pretraining framework designed for cryo-EM density maps. CryoProt introduces a ...
| Authors | Dan Luo, Xuan Lin, Peng Zhou et al. |
|---|---|
| Primary category | cs.LG |
| Published | 31 May 2026 |
| Last updated at source | 31 May 2026 |
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