Subcortical Shape Variations and Their Associations with Cognition Across the 8th Decade of Life. A Study in the Lothian Birth Cohort 1936
The study of brain morphology changes in normal individuals may capture aspects of functionally-relevant brain aging not fully indicated by gross volumetry. Despite the important role of subcortical brain structures in cognition, the associations between their morphological trajectories and cognitive changes in aging have not been documented. We use neuroimaging, demographic, and cognitive data from a large longitudinal study of cognitive aging, the Lothian Birth Cohort 1936, to explore shape changes in subcortical brain structures of community-dwelling individuals across their 8th decade of life. We investigate the association of these changes with cognitive aging using ANCOVA and mixed ...
| Authors | Maria del C. Valdes-Hernandez, Wonjung Park, Joanna Moodie et al. |
|---|---|
| Primary category | q-bio.NC |
| Published | 28 May 2026 |
| Last updated at source | 28 May 2026 |
Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.