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Paper · arXiv

Causal Intelligence for Constraint-Aware Intervention Design to Induce State Transitions

Driving a system from one state to another through targeted interventions is a fundamental challenge in science, yet most predictive models offer limited mechanistic insight and no principled framework for decision-making. Here we present COAST (Causally Optimal Actions for State Transitions), a causal-intelligence approach for the in-silico design of constrained interventions that induce user-defined state transitions. Given data characterizing source and target states, COAST learns context-specific causal graphs and structural causal models, attributes observed distributional shifts to mechanism-level causal drivers, and introduces a novel constraint-aware multi-objective optimization f...

AuthorsZixuan Song, Uwe Mueller, Dimitris V. Manatakis
Primary categorycs.LG
Published27 May 2026
Last updated at source27 May 2026
cs.LG
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