The Biosecurity Blind Spot: Systematic Dual-use Detection in Open Science Infrastructure
AI is transforming life sciences research at unprecedented speed, accelerating discovery across protein structure prediction, genome modeling, and drug development (Jumper et al., 2021; Mak et al., 2024). Yet this rapid advancement, coupled with the open science movement, introduces significant dual-use research concerns that have received limited empirical scrutiny. Here we present the first systematic analysis of dual-use research of concern (DURC) content on open preprint servers. We screened ~52,000 bioRxiv preprints (2024-2025) using a hybrid pipeline of lexical filtering and large language model (LLM) evaluation, scoring metadata across nine DURC, three PEPP, and five governance cat...
| Authors | Vasudha Sharma, Chakresh Kumar Singh, Jayesh Choudhari et al. |
|---|---|
| Primary category | cs.DL |
| Published | 10 May 2026 |
| Last updated at source | 10 May 2026 |
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