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Paper · arXiv

SEMA-RAG: A Self-Evolving Multi-Agent Retrieval-Augmented Generation Framework for Medical Reasoning

Retrieval-Augmented Generation (RAG) is widely employed to mitigate risks such as hallucinations and knowledge obsolescence in medical question answering, yet its predominantly single-round, static retrieval paradigm misaligns with the multi-stage process of clinical reasoning. This compressed workflow induces two structural deficiencies: question-to-query translation often lacks clinically grounded semantic interpretation, and retrieval lacks iterative sufficiency feedback, making it difficult to form reliable evidence chains. We argue that both issues stem from a deeper cause: overloading a single reasoning chain with heterogeneous tasks of interpretation, exploration, and adjudication....

AuthorsYongfeng Huang, Ruiying Chen, James Cheng
Primary categorycs.CL
Published16 May 2026
Last updated at source29 May 2026
cs.CLcs.AI
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