PRISM: Perinuclear Ring-based Image Segmentation Method for Acute Lymphoblastic Leukemia Classification
Automated analysis of peripheral blood smears for Acute Lymphoblastic Leukemia (ALL) is hindered by low contrast and substantial variability in cytoplasmic appearance, which complicate conventional membrane-based segmentation. We found that many recent approaches rely on heavy neural architectures and extensive training, but still struggle to generalize across staining and acquisition variability. To address these limitations, we propose the Perinuclear Ring-based Image Segmentation Method (PRISM), which replaces explicit cytoplasmic delineation with adaptive concentric zones constructed around the nucleus. These perinuclear regions enable the extraction of robust cytoplasmic descriptors ...
| Authors | Larissa Ferreira Rodrigues Moreira, Leonardo Gabriel Ferreira Rodrigues, Rodrigo Moreira et al. |
|---|---|
| Primary category | cs.CV |
| Published | 13 May 2026 |
| Last updated at source | 13 May 2026 |
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