When Brains Disagree: Biological Ambiguity Underlies the Challenge of Amyloid PET Synthesis from Structural MRI
Structural MRI-to-amyloid PET synthesis has been proposed as a non-invasive alternative for amyloid assessment in Alzheimer's disease (AD). However, reported performance of identical models varies widely across studies, and increasingly complex architectures have not led to consistent gains. This inconsistency is thought to be caused by a fundamental biological ambiguity: MRI captures neurodegeneration, while PET measures amyloid pathology - two processes that are often temporally decoupled in AD. As a result, similar MRI patterns may correspond to different amyloid states, creating ambiguous one-to-many mappings. MRI-to-amyloid PET synthesis may therefore be intrinsically ill-posed; howe...
| Authors | Louise E. G. Baron, Ross Callaghan, David M. Cash et al. |
|---|---|
| Primary category | cs.CV |
| Published | 12 May 2026 |
| Last updated at source | 26 May 2026 |
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