Unlocking LLM Creativity in Science through Analogical Reasoning

Autonomous science promises to augment scientific discovery, particularly in complex fields like biomedicine. However, this requires AI systems that can consistently generate novel and diverse solutions to open-ended problems. We evaluate LLMs on the task of open-ended solution generation and quantify their tendency to mode collapse into low-diversity generations. To mitigate this mode collapse, we introduce analogical reasoning (AR) as a new approach to solution generation. AR generates analogies to cross-domain problems based on shared relational structure, then uses those analogies to search for novel solutions. Compared to baselines, AR discovers significantly more diverse generations...

<iframe src="https://silytics.si/embed/item/9c53153e-bc22-4e8e-8d72-6b90830dd25c" width="420" height="190" style="border:0" loading="lazy" title="Silytics entry"></iframe>

Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.