SCOPE: Siamese Contrastive Operon Pair Embeddings for Functional Sequence Representation and Classification
Identifying operons is a fundamental step in understanding prokaryotic gene regulation, as classifying genes into operons supports the reconstruction of regulatory networks, functional annotation of unannotated genes, and drug candidate development. Experimental approaches such as RT-PCR and RNA-seq provide precise evidence of operon structure, but are laborious and largely limited to well-studied model organisms, making scalable computational methods essential for genome-wide operon identification. Prior computational approaches have employed traditional classifiers such as logistic regression and decision trees, motivating our use of these as physicochemical baselines. The DGEB benchmar...
| Authors | Akarsh Gupta, Kenneth Rodrigues, Sagnik Chatterjee |
|---|---|
| Primary category | q-bio.GN |
| Published | 10 May 2026 |
| Last updated at source | 10 May 2026 |
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