MicroFuse: Protein-to-Genome Expert Fusion for Microbial Operon Reasoning
Predicting microbial operon co-membership requires integrating two complementary biological signals: protein-scale molecular identity and genome-context organization. While recent biological foundation models provide powerful representations of each view independently, naive concatenation of these modalities ignores a key biological property -- protein identity and genomic context may agree when adjacent genes form a coherent functional module, or conflict when sequence similarity is misleading but genomic layout indicates independent regulation. We present MicroFuse, a protein-to-genome expert fusion framework that integrates structure-aware protein representations from ProstT5 with geno...
| Authors | Seungik Cho |
|---|---|
| Primary category | cs.LG |
| Published | 9 May 2026 |
| Last updated at source | 9 May 2026 |
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