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Paper · arXiv

Flow Matching for Count Data

High-dimensional count data arise in applications such as single-cell RNA sequencing and neural spike trains, where mappings between distributions across successive batches or time points form critical components of data analysis. The recent success of diffusion- and flow-based deep generative models for images, video, and text motivates extending these ideas to count-valued settings, but many existing methods either treat each count as a categorical state or transform counts into a continuous space, neither of which is natural or efficient when the count range is large. We propose count-FM, a flow-matching framework for count data based on a continuous-time birth-death process with local...

AuthorsGanchao Wei, John Pearson
Primary categorystat.ML
Published8 May 2026
Last updated at source22 September 2026
stat.MLcs.LGq-bio.QM
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