A-CODE: Fully Atomic Protein Co-Design with Unified Multimodal Diffusion
We present A-CODE, a fully atomic unified one-stage protein co-design model that simultaneously refines discrete atom types and continuous atom coordinates. Unlike predominant two-stage methods that cascade structure design with amino acid-level sequence design, our approach is fully atomic within a unified multimodal diffusion framework, in which residue identities are inferred solely from atom-level predictions. Built upon the powerful all-atom architecture, A-CODE achieves superior designability for unconditional protein generation, outperforming all existing one-stage and two-stage design models. For binder design, A-CODE rivals and even outperforms existing state-of-the-art two-stage...
| Authors | Chaoran Cheng, Jiaqi Guan, Milong Ren et al. |
|---|---|
| Primary category | q-bio.QM |
| Published | 5 May 2026 |
| Last updated at source | 5 May 2026 |
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