Agentic clinical reasoning over longitudinal myeloma records: a retrospective evaluation against expert consensus
Multiple myeloma is managed through sequential lines of therapy over years to decades, with each decision depending on cumulative disease history distributed across dozens to hundreds of heterogeneous clinical documents. Whether LLM-based systems can synthesise this evidence at a level approaching expert agreement has not been established. A retrospective evaluation was conducted on longitudinal clinical records of 811 myeloma patients treated at a tertiary centre (2001-2026), covering 44,962 documents and 1,334,677 laboratory values, with external validation on MIMIC-IV. An agentic reasoning system was compared against single-pass retrieval-augmented generation (RAG), iterative RAG, and ...
| Authors | Johannes Moll, Jannik Lübberstedt, Christoph Nuernbergk et al. |
|---|---|
| Primary category | cs.AI |
| Published | 27 April 2026 |
| Last updated at source | 27 April 2026 |
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