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Paper · arXiv

Agentic AI platforms for autonomous training and rule induction of human-human and virus-human protein-protein interactions

We instruct an AI agent to construct two separate agentic AI platforms: one for autonomous training of predictive ML models for human-human and virus-human PPI, and the other for inducing explicit general rules governing human-human and virus-human PPI. The first agentic AI platform for autonomous training of predictive ML models for PPI is designed to consist of five AI agents that handle autonomous data collection, data verification, feature embedding, model design, and training and validation on three-way protein-disjoint cross-fold datasets. For human-human and human-virus PPIs, the final three-way protein-disjoint ensemble achieves an accuracy of 87.3% and 86.5%, respectively. For cr...

AuthorsHung N. Do, Jessica Z. Kubicek-Sutherland, Oscar A. Negrete et al.
Primary categorycs.AI
Published27 April 2026
Last updated at source27 April 2026
cs.AIq-bio.BM
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