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Paper · arXiv

An Integrated Framework for Explainable, Fair, and Observable Hospital Readmission Prediction: Development and Validation on MIMIC-IV

Objective: To propose and retrospectively validate an integrated framework addressing three barriers to clinical translation of readmission prediction: lack of explainability, absence of deployment reliability infrastructure, and inadequate demographic fairness evaluation. Materials and Methods: We constructed a cohort of 415231 adult admissions from the MIMIC-IV database (30-day readmission prevalence 18.0%), split 70/15/15. Logistic regression, XGBoost, and LightGBM models were trained on 26 features. SHAP provided per-patient explanations. Fairness was evaluated across 16 subgroups using AUC-ROC, false negative rate (FNR), and positive predictive value (PPV). Calibration was assessed u...

AuthorsIsaac Tosin Adisa
Primary categorycs.LG
Published24 April 2026
Last updated at source5 May 2026
cs.LG
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