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Paper · arXiv

Trustworthy Clinical Decision Support Using Meta-Predicates and Domain-Specific Languages

\textbf{Background:} Regulatory frameworks for AI in healthcare, including the EU AI Act and FDA guidance on AI/ML-based medical devices, require clinical decision support to demonstrate not only accuracy but auditability. Existing formal languages for clinical logic validate syntactic and structural correctness but not whether decision rules use epistemologically appropriate evidence. \textbf{Methods:} Drawing on design-by-contract principles, we introduce meta-predicates -- predicates about predicates -- for asserting epistemological constraints on clinical decision rules expressed in a DSL. An epistemological type system classifies annotations along four dimensions: purpose, knowledge ...

AuthorsMichael Bouzinier, Sergey Trifonov, Michael Chumack et al.
Primary categorycs.AI
Published23 April 2026
Last updated at source23 April 2026
cs.AIcs.PLcs.SEq-bio.QM
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