Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging
Retinal laser speckle contrast imaging (LSCI) is a noninvasive optical modality for monitoring retinal blood flow dynamics. However, conventional temporal LSCI (tLSCI) reconstruction relies on sufficiently long speckle sequences to obtain stable temporal statistics, which makes it vulnerable to acquisition disturbances and limits effective temporal resolution. A physically informed reconstruction framework, termed RetinaDiff (Retinal Diffusion Model), is proposed for retinal tLSCI that is robust to motion and requires only a few frames. In RetinaDiff, registration based on phase correlation is first applied to stabilize the raw speckle sequence before contrast computation, reducing interf...
| Authors | Qian Chen, Yuehao Chen, Qiang Wang et al. |
|---|---|
| Primary category | cs.CV |
| Published | 22 April 2026 |
| Last updated at source | 6 October 2026 |
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