ConforNets: Latents-Based Conformational Control in OpenFold3
Models from the AlphaFold (AF) family reliably predict one dominant conformation for most well-ordered proteins but struggle to capture biologically relevant alternate states. Several efforts have focused on eliciting greater conformational variability through ad hoc inference-time perturbations of AF models or their inputs. Despite their progress, these approaches remain inefficient and fail to consistently recover major conformational modes. Here, we investigate both the optimal location and manner-of-operation for perturbing latent representations in the AF3 architecture. We distill our findings in ConforNets: channel-wise affine transforms of the pre-Pairformer pair latents. Unlike pr...
| Authors | Minji Lee, Colin Kalicki, Minkyu Jeon et al. |
|---|---|
| Primary category | q-bio.BM |
| Published | 20 April 2026 |
| Last updated at source | 20 April 2026 |
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