A Two-Stage Multi-Modal MRI Framework for Lifespan Brain Age Prediction
The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture the coordinated macro- and microstructural changes that unfold across the human lifespan. To address these limitations, we develop a multi-modal brain age framework to characterize the integrated evolution of brain morphology and white matter organization. Our model adopts a two-stage architecture, where modalities are processed independently and integrated via late fusion in both stages: first to estimate a probability distribution over six developmen...
| Authors | Dingyi Zhang, Ruiying Liu, Yun Wang |
|---|---|
| Primary category | eess.IV |
| Published | 17 April 2026 |
| Last updated at source | 17 September 2026 |
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