Towards Autonomous Mechanistic Reasoning in Virtual Cells
Large language models (LLMs) have recently gained significant attention as a promising approach to accelerate scientific discovery. However, their application in open-ended scientific domains such as biology remains limited, primarily due to the lack of factually grounded and actionable explanations. To address this, we introduce a structured explanation formalism for virtual cells that represents biological reasoning as mechanistic action graphs, enabling systematic verification and falsification. Building upon this, we propose VCR-Agent, a multi-agent framework that integrates biologically grounded knowledge retrieval with a verifier-based filtering approach to generate and validate mec...
| Authors | Yunhui Jang, Lu Zhu, Jake Fawkes et al. |
|---|---|
| Primary category | cs.LG |
| Published | 13 April 2026 |
| Last updated at source | 20 May 2026 |
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