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Paper · arXiv

When AI and Experts Agree on Error: Intrinsic Ambiguity in Dermatoscopic Images

The integration of artificial intelligence (AI), particularly Convolutional Neural Networks (CNNs), into dermatological diagnosis demonstrates substantial clinical potential. While existing literature predominantly benchmarks algorithmic performance against human experts, our study adopts a novel perspective by investigating the intrinsic complexity of dermatoscopic images. Through rigorous experimentation with multiple CNN architectures, we isolated a subset of images systematically misclassified across all models-a phenomenon statistically proven to exceed random chance. To determine if these failures stem from algorithmic biases or inherent visual ambiguity, expert dermatologists indep...

AuthorsLoris Cino, Pier Luigi Mazzeo, Alessandro Martella et al.
Primary categorycs.CV
Published1 April 2026
Last updated at source1 April 2026
cs.CV
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