Neuropsychiatric Deviations From Normative Profiles: An MRI-Derived Marker for Early Alzheimer's Disease Detection
Neuropsychiatric symptoms (NPS) such as depression and apathy are common in Alzheimer's disease (AD) and often precede cognitive decline. NPS assessments hold promise as early detection markers due to their correlation with disease progression and their non-invasive nature. Yet current tools cannot distinguish whether NPS are part of aging or early signs of AD, limiting their utility. We present a deep learning-based normative modelling framework to identify atypical NPS burden from structural MRI. A 3D convolutional neural network was trained on cognitively stable participants from the Alzheimer's Disease Neuroimaging Initiative, learning the mapping between brain anatomy and Neuropsychi...
| Authors | Synne Hjertager Osenbroch, Lisa Ramona Rosvold, Yao Lu et al. |
|---|---|
| Primary category | cs.CV |
| Published | 1 April 2026 |
| Last updated at source | 1 April 2026 |
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