Improving Generalization of Deep Learning for Brain Metastases Segmentation Across Institutions
Background: Deep learning has demonstrated significant potential for automated brain metastases (BM) segmentation; however, models trained at a singular institution often exhibit suboptimal performance at various sites due to disparities in scanner hardware, imaging protocols, and patient demographics. The goal of this work is to create a domain adaptation framework that will allow for BM segmentation to be used across multiple institutions. Methods: We propose a VAE-MMD preprocessing pipeline that combines variational autoencoders (VAE) with maximum mean discrepancy (MMD) loss, incorporating skip connections and self-attention mechanisms alongside nnU-Net segmentation. The method was tes...
| Authors | Yuchen Yang, Shuangyang Zhong, Haijun Yu et al. |
|---|---|
| Primary category | cs.CV |
| Published | 1 April 2026 |
| Last updated at source | 1 April 2026 |
Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.