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Paper · arXiv

A Boltzmann-machine-enhanced Transformer For DNA Sequence Classification

DNA sequence classification requires not only high predictive accuracy but also the ability to uncover latent site interactions, combinatorial regulation, and epistasis-like higher-order dependencies. Although the standard Transformer provides strong global modeling capacity, its softmax attention is continuous, dense, and weakly constrained, making it better suited for information routing than explicit structure discovery. In this paper, we propose a Boltzmann-machine-enhanced Transformer for DNA sequence classification. Built on multi-head attention, the model introduces structured binary gating variables to represent latent query-key connections and constrains them with a Boltzmann-sty...

AuthorsZhixuan Cao, Yishu Xu, Xuang WU
Primary categorycs.LG
Published27 March 2026
Last updated at source27 March 2026
cs.LGcs.AI
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