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Paper · arXiv

Integrating Causal Machine Learning into Clinical Decision Support Systems: Insights from Literature and Practice

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering interpretable, treatment-specific reasoning. However, existing research often emphasizes model development rather than designing clinician-facing interfaces. To address this gap, we investigated how CDSSs based on causal ML should be designed to effectively support collaborative clinical decision-making. Using a design science research methodology, we conducted a structured literature review and interviewed experienced physicians. From these, we derive...

AuthorsDomenique Zipperling, Lukas Schmidt, Benedikt Hahn et al.
Primary categorycs.HC
Published25 March 2026
Last updated at source16 April 2026
cs.HCcs.AI
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