Hierarchical Multiscale Structure-Function Coupling for Brain Connectome Integration
Integrating structural and functional connectomes remains challenging because their relationship is non-linear and organized over nested modular hierarchies. We propose a hierarchical multiscale structure-function coupling framework for connectome integration that jointly learns individualized modular organization and hierarchical coupling across structural connectivity (SC) and functional connectivity (FC). The framework includes: (i) Prototype-based Modular Pooling (PMPool), which learns modality-specific multiscale communities by selecting prototypical ROIs and optimizing a differentiable modularity-inspired objective; (ii) an Attention-based Hierarchical Coupling Module (AHCM) that mo...
| Authors | Jianwei Chen, Zhengyang Miao, Wenjie Cai et al. |
|---|---|
| Primary category | q-bio.NC |
| Published | 21 March 2026 |
| Last updated at source | 21 March 2026 |
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