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Paper · arXiv

A Comprehensive Benchmark of Histopathology Foundation Models for Kidney Digital Pathology Images

Histopathology foundation models (HFMs), pretrained on large-scale cancer datasets, have advanced computational pathology. However, their applicability to non-cancerous chronic kidney disease remains underexplored, despite coexistence of renal pathology with malignancies such as renal cell and urothelial carcinoma. We systematically evaluate 11 publicly available HFMs across 11 kidney-specific downstream tasks spanning multiple stains (PAS, H&E, PASM, and IHC), spatial scales (tile and slide-level), task types (classification, regression, and copy detection), and clinical objectives, including detection, diagnosis, and prognosis. Tile-level performance is assessed using repeated stratifie...

AuthorsHarishwar Reddy Kasireddy, Patricio S. La Rosa, Akshita Gupta et al.
Primary categorycs.CV
Published16 March 2026
Last updated at source18 March 2026
cs.CV
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