Deep EM with Hierarchical Latent Label Modelling for Multi-Site Prostate Lesion Segmentation
Label variability is a major challenge for prostate lesion segmentation. In multi-site datasets, annotations often reflect centre-specific contouring protocols, causing segmentation networks to overfit to local styles and generalise poorly to unseen sites in inference. We treat each observed annotation as a noisy observation of an underlying latent 'clean' lesion mask, and propose a hierarchical expectation-maximisation (HierEM) framework that alternates between: (1) inferring a voxel-wise posterior distribution over the latent mask, and (2) training a CNN using this posterior as a soft target and estimate site-specific sensitivity and specificity under a hierarchical prior. This hierarch...
| Authors | Wen Yan, Yipei Wang, Shiqi Huang et al. |
|---|---|
| Primary category | cs.CV |
| Published | 15 March 2026 |
| Last updated at source | 20 June 2026 |
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