CHIMERA-Bench: A Benchmark Dataset for Epitope-Specific Antibody Design
Computational antibody design has seen rapid methodological progress, with dozens of deep generative methods proposed in the past three years, yet the field lacks a standardized benchmark for fair comparison and model development. These methods are evaluated on different SAbDab snapshots, non-overlapping test sets, and incompatible metrics, and the literature fragments the design problem into numerous sub-tasks with no common definition. We introduce CHIMERA-Bench: (CDR Modeling with Epitope-guided Redesign), a unified benchmark built around a single canonical task: epitope-conditioned CDR sequence-structure co-design. CHIMERA-Bench provides three components. The first is a curated, dedup...
| Authors | Mansoor Ahmed, Nadeem Taj, Imdad Ullah Khan et al. |
|---|---|
| Primary category | cs.LG |
| Published | 13 March 2026 |
| Last updated at source | 5 June 2026 |
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