Association of Progressive PPFE and Mortality in Lung Cancer Screening Cohorts
Background: Pleuroparenchymal fibroelastosis (PPFE) is an upper lobe predominant fibrotic lung abnormality associated with increased mortality in established interstitial lung disease. However, the clinical significance of radiologic PPFE progression in lung cancer screening (LCS) populations remains unclear. Methods: We analysed longitudinal low-dose CT scans and clinical data from two LCS studies: National Lung Screening Trial (NLST; n=7,980); SUMMIT study (n=8,561). An automated algorithm quantified PPFE volume on baseline and follow-up scans. Annualised change in PPFE was derived and dichotomised using a distribution-based threshold to define progressive PPFE. Associations between pro...
| Authors | Shahab Aslani, Mehran Azimbagirad, Daryl Cheng et al. |
|---|---|
| Primary category | q-bio.QM |
| Published | 10 March 2026 |
| Last updated at source | 17 March 2026 |
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