Class Visualizations and Activation Atlases for Enhancing Interpretability in Deep Learning-Based Computational Pathology
The rapid adoption of transformer-based models in computational pathology has enabled prediction of molecular and clinical biomarkers from H&E whole-slide images, yet interpretability has not kept pace with model complexity. While attribution- and generative-based methods are common, feature visualization approaches such as class visualizations (CVs) and activation atlases (AAs) have not been systematically evaluated for these models. We developed a visualization framework and assessed CVs and AAs for a transformer-based foundation model across tissue and multi-organ cancer classification tasks with increasing label granularity. Four pathologists annotated real and generated images to qua...
| Authors | Marco Gustav, Fabian Wolf, Christina Glasner et al. |
|---|---|
| Primary category | cs.CV |
| Published | 7 March 2026 |
| Last updated at source | 10 March 2026 |
Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.