Spinverse: Differentiable Physics for Permeability-Aware Microstructure Reconstruction from Diffusion MRI
Diffusion MRI (dMRI) is sensitive to microstructural barriers, yet most existing methods either assume impermeable boundaries or estimate voxel-level parameters without recovering explicit interfaces. We present Spinverse, a permeability-aware reconstruction method that inverts dMRI measurements through a fully differentiable Bloch-Torrey simulator. Spinverse represents tissue on a fixed tetrahedral grid and treats each interior face permeability as a learnable parameter; low-permeability faces act as diffusion barriers, so microstructural boundaries whose topology is not fixed a priori (up to the resolution of the ambient mesh) emerge without changing mesh connectivity or vertex position...
| Authors | Prathamesh Pradeep Khole, Mario M. Brenes, Zahra Kais Petiwala et al. |
|---|---|
| Primary category | cs.CV |
| Published | 4 March 2026 |
| Last updated at source | 4 March 2026 |
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