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Paper · arXiv

ProtRLSearch: A Multi-Round Multimodal Protein Search Agent with Large Language Models Trained via Reinforcement Learning

Protein analysis tasks arising in healthcare settings often require accurate reasoning under protein sequence constraints, involving tasks such as functional interpretation of disease-related variants, protein-level analysis for clinical research, and similar scenarios. To address such tasks, search agents are introduced to search protein-related information, providing support for disease-related variant analysis and protein function reasoning in protein-centric inference. However, such search agents are mostly limited to single-round, text-only modality search, which prevents the protein sequence modality from being incorporated as a multimodal input into the search decision-making proce...

AuthorsCongying Liu, Taihao Li, Ming Huang et al.
Primary categorycs.AI
Published2 March 2026
Last updated at source2 March 2026
cs.AIcs.CL
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