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Paper · arXiv

Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influence

Fine-tuning-as-a-service introduces a threat to Large Language Models' safety when service providers fine-tune their models on poisoned user-submitted datasets, a process known as harmful fine-tuning attacks. In this work, we show that by regularizing the gradient contribution of harmful samples encountered during fine-tuning, we can effectively mitigate the impact of harmful fine-tuning attacks. To this end, we introduce Antibody, a defense strategy that first ensures robust safety alignment for the model before fine-tuning, and then applies a safety-preservation learning algorithm during fine-tuning. Specifically, in the alignment stage before fine-tuning, we propose optimizing the mode...

AuthorsQuoc Minh Nguyen, Trung Le, Jing Wu et al.
Primary categorycs.LG
Published28 February 2026
Last updated at source28 February 2026
cs.LG
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