RosettaCommons/MegaScale

Mega-scale experimental analysis of protein folding stability in biology and design The full MegaScale dataset contains 1,841,285 thermodynamic folding stability measurements using cDNA display proteolysis of natural and designed proteins. From these 776,298 high-quality folding stabilities (dataset2) cover all single amino acid variants and selected double mutants of 331 natural and 148 de novo designed protein domains 40–72 amino acids in length. Of these mutations, 607,839 have… See the full description on the dataset page: https://huggingface.co/datasets/RosettaCommons/MegaScale.

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